The Pills Wiki
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From Uncle George's letter:

« Orange pills increase libido and sexual needs. They also turn your hair red.»

Primary Effects

Orange Pills are about increasing John's libido and give traits related to sexual pleasure. The orange pill is also the pill that governs sexual orientation, determined by your gender when taking your first orange pill. You become attracted to the opposite of your current gender.

Gender Orientation Description
Man Gynophile Attraction to Women
Woman Androphile Attraction to Men
Hermaphrodite Futaphile Attraction to Futanari
Futanari Hermaphile Attraction to Hermaphrodites
Cuntboy Cockophile Attraction to Penises
Dickgirl Vaginophile Attraction to Vaginas
Any with two

pills in a row

Bisexual Attraction to all Genders

After acquiring you initial orientation it doesn't change, but gets redefined if your gender changes. A man attracted to women that becomes a woman will still be attracted to them, but Gynophile will become Lesbian, and the same holds true for a Androphilic woman that becomes a Gay man. The only exception is Bisexual, as any orientation will change to bisexual when John takes two successive Orange Pills.

Portraits

Base First Pill Second Pill Third Pill
Basic
Basic Man
Rakish
Rakish
Lecherous
Lecherous
Satyromaniac
Satyromaniac
Pretty
Pretty or Basic Woman
Easy
Easy
Slutty
Slutty
Nymphomaniac
Nymphomaniac
Himbo
Himbo
Chaser
Chaser
Playboy
Playboy
Model
Model
Bimbo
Bimbo
Bombshell
Bombshell
Dreamy
Dreamy
Pin-up
Pinup
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